Simulations of Nonthermal Electron Transport in Multidimensional Flows: Synthetic Observations of Radio Galaxies

We have applied an effective numerical scheme for cosmic-ray transport to 3D MHD simulations of jet flow in radio galaxies (see the companion paper by Jones et al. 1999). The marriage of relativistic particle and 3D magnetic field information allows us to construct a rich set of ``synthetic observations'' of our simulated objects. The information is sufficient to calculate the ``true'' synchrotron emissivity at a given frequency using explicit information about the relativistic electrons. This enables us to produce synchrotron surface-brightness maps, including polarization. Inverse-Compton X-ray surface-brightness maps may also be produced. First results intended to explore the connection between jet dynamics and electron transport in radio lobes are discussed. We infer lobe magnetic field values by comparison of synthetically observed X-ray and synchrotron fluxes, and find these ``inverse-Compton'' fields to be quite consistent with the actual RMS field averaged over the lobe. The simplest minimum energy calculation from the synthetic observations also seems to agree with the actual simulated source properties.Comment: 7 pages, 1 figure; to appear in Life Cycles of Radio Galaxies, ed. J. Biretta et al., New Astronomy Review

Simulations of Nonthermal Electron Transport in Multidimensional Flows: Application to Radio Galaxies

We have developed an economical, effective numerical scheme for cosmic-ray transport suitable for treatment of electrons up to a few hundreds of GeV in multidimensional simulations of radio galaxies. The method follows the electron population in sufficient detail to allow computation of synthetic radio and X-ray observations of the simulated sources, including spectral properties (see the companion paper by Tregillis et al. 1999). The cosmic-ray particle simulations can follow the effects of shock acceleration, second-order Fermi acceleration as well as radiative and adiabatic energy losses. We have applied this scheme to 2-D and 3-D MHD simulations of jet-driven flows and have begun to explore links between dynamics and the properties of high energy electron populations in radio lobes. The key initial discovery is the great importance to the high energy particle population of the very unsteady and inhomogeneous flows, especially near the end of the jet. Because of this, in particular, our simulations show that a large fraction of the particle population flowing from the jet into the cocoon never passes through strong shocks. The shock strengths encountered are not simply predicted by 1-D models, and are quite varied. Consequently, the emergent electron spectra are highly heterogeneous. Rates of synchrotron aging in "hot-spots" seem similarly to be very uneven, enhancing complexity in the spectral properties of electrons as they emerge into the lobes and making more difficult the task of comparing dynamical and radiative ages.Comment: 7 pages, 1 figure; to appear in Life Cycles of Radio Galaxies, ed. J. Biretta et al., New Astronomy Review

Autonomous Gossiping: A self-organizing epidemic algorithm for selective information dissemination in mobile ad-hoc networks

We introduce autonomous gossiping (A/G), a new genre epidemic algorithm for selective dissemination of information in contrast to previous usage of epidemic algorithms which flood the whole network. A/G is a paradigm which suits well in a mobile ad-hoc networking (MANET) environment because it does not require any infrastructure or middleware like multicast tree and (un)subscription maintenance for publish/subscribe, but uses ecological and economic principles in a self-organizing manner in order to achieve its selectivity. The trade-off of using an infrastructure-less self-organizing mechanism like A/G is that it does not guarantee completeness deterministically as is one of the original objectives of alternate selective dissemination schemes like publish/subscribe. We argue that such incompleteness is not a problem in many non-critical real-life civilian application scenarios and realistic node mobility patterns, where the overhead of infrastructure maintenance may outweigh the benefits of completeness, more over, at present there exists no mechanism to realize publish/subscribe or other paradigms for selective dissemination in MANET environments. A/G's reliance and hence vulnerability on cooperation of mobile nodes is also much less as compared to other possible schemes using routing information, since it does not expect node philanthropy for forwarding/carrying information, but only cooperation to the extent that nodes already carrying the information pass it on to other suitable ones. Thus autonomous gossiping is expected to be a light-weight infrastructure-less information dissemination service for MANETs, and hence support any-to-many communication (flexible casting) without the need to establish and maintain separate routing information (e.g., multicast trees)

Modeling magnetospheric fields in the Jupiter system

The various processes which generate magnetic fields within the Jupiter system are exemplary for a large class of similar processes occurring at other planets in the solar system, but also around extrasolar planets. Jupiter's large internal dynamo magnetic field generates a gigantic magnetosphere, which is strongly rotational driven and possesses large plasma sources located deeply within the magnetosphere. The combination of the latter two effects is the primary reason for Jupiter's main auroral ovals. Jupiter's moon Ganymede is the only known moon with an intrinsic dynamo magnetic field, which generates a mini-magnetosphere located within Jupiter's larger magnetosphere including two auroral ovals. Ganymede's magnetosphere is qualitatively different compared to the one from Jupiter. It possesses no bow shock but develops Alfv\'en wings similar to most of the extrasolar planets which orbit their host stars within 0.1 AU. New numerical models of Jupiter's and Ganymede's magnetospheres presented here provide quantitative insight into the processes that maintain these magnetospheres. Jupiter's magnetospheric field is approximately time-periodic at the locations of Jupiter's moons and induces secondary magnetic fields in electrically conductive layers such as subsurface oceans. In the case of Ganymede, these secondary magnetic fields influence the oscillation of the location of its auroral ovals. Based on dedicated Hubble Space Telescope observations, an analysis of the amplitudes of the auroral oscillations provides evidence that Ganymede harbors a subsurface ocean. Callisto in contrast does not possess a mini-magnetosphere, but still shows a perturbed magnetic field environment. Callisto's ionosphere and atmospheric UV emission is different compared to the other Galilean satellites as it is primarily been generated by solar photons compared to magnetospheric electrons.Comment: Chapter for Book: Planetary Magnetis

Ultrasound-directed enzyme-prodrug therapy (UDEPT) using self-immolative doxorubicin derivatives

Background: Enzyme-activatable prodrugs are extensively employed in oncology and beyond. Because enzyme concentrations and their (sub)cellular compartmentalization are highly heterogeneous in different tumor types and patients, we propose ultrasound-directed enzyme-prodrug therapy (UDEPT) as a means to increase enzyme access and availability for prodrug activation locally. Methods: We synthesized β-glucuronidase-sensitive self-immolative doxorubicin prodrugs with different spacer lengths between the active drug moiety and the capping group. We evaluated drug conversion, uptake and cytotoxicity in the presence and absence of the activating enzyme β-glucuronidase. To trigger the cell release of β-glucuronidase, we used high-intensity focused ultrasound to aid in the conversion of the prodrugs into their active counterparts. Results: More efficient enzymatic activation was observed for self-immolative prodrugs with more than one aromatic unit in the spacer. In the absence of β-glucuronidase, the prodrugs showed significantly reduced cellular uptake and cytotoxicity compared to the parent drug. High-intensity focused ultrasound-induced mechanical destruction of cancer cells resulted in release of intact β-glucuronidase, which activated the prodrugs, restored their cytotoxicity and induced immunogenic cell death. Conclusion: These findings shed new light on prodrug design and activation, and they contribute to novel UDEPT-based mechanochemical combination therapies for the treatment of cancer

Management of Patients With High Baseline Hip Fracture Risk by FRAX Reduces Hip Fractures-A Post Hoc Analysis of the SCOOP Study.

The Screening for Osteoporosis in Older Women for the Prevention of Fracture (SCOOP) study was a community-based screening intervention in women aged 70 to 85 years in the United Kingdom. In the screening arm, licensed osteoporosis treatments were recommended in women identified to be at high risk of hip fracture using the FRAX risk assessment tool (including bone mineral density measurement). In the control arm, standard care was provided. Screening led to a 28% reduction in hip fractures over 5 years. In this planned post hoc analysis, we wished to examine for interactions between screening effectiveness on fracture outcome (any, osteoporotic, and hip fractures) on the one hand and baseline FRAX 10-year probability of hip fracture on the other. All analyses were conducted on an intention-to-treat basis, based on the group to which women were randomized, irrespective of whether screening was completed. Of 12,483 eligible participants, 6233 women were randomized to screening, with treatment recommended in 898 (14.4%). No evidence of an effect or interaction was observed for the outcomes of any fracture or osteoporotic fracture. In the screening arm, 54 fewer hip fractures were observed than in the control arm (164 versus 218, 2.6% versus 3.5%), and commensurate with treatment being targeted to those at highest hip fracture risk, the effect on hip fracture increased with baseline FRAX hip fracture probability (p = 0.021 for interaction); for example, at the 10th percentile of baseline FRAX hip probability (2.6%), there was no evidence that hip fractures were reduced (hazard ratio [HR] = 0.93; 95% confidence interval [CI] 0.71 to 1.23), but at the 90th percentile (16.6%), there was a 33% reduction (HR = 0.67; 95% CI 0.53 to 0.84). Prior fracture and parental history of hip fracture positively influenced screening effectiveness on hip fracture risk. We conclude that women at high risk of hip fracture based on FRAX probability are responsive to appropriate osteoporosis management. © 2018 American Society for Bone and Mineral Research

Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma.

We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases. We identified co-segregating mutations in histone-mutant subgroups including loss of FBXW7 in H3.3G34R/V, TOP3A rearrangements in H3.3K27M, and BCOR mutations in H3.1K27M. Histone wild-type subgroups are refined by the presence of key oncogenic events or methylation profiles more closely resembling lower-grade tumors. Genomic aberrations increase with age, highlighting the infant population as biologically and clinically distinct. Uncommon pathway dysregulation is seen in small subsets of tumors, further defining the molecular diversity of the disease, opening up avenues for biological study and providing a basis for functionally defined future treatment stratification

Non-thermal processes in cosmological simulations

Non-thermal components are key ingredients for understanding clusters of galaxies. In the hierarchical model of structure formation, shocks and large-scale turbulence are unavoidable in the cluster formation processes. Understanding the amplification and evolution of the magnetic field in galaxy clusters is necessary for modelling both the heat transport and the dissipative processes in the hot intra-cluster plasma. The acceleration, transport and interactions of non-thermal energetic particles are essential for modelling the observed emissions. Therefore, the inclusion of the non-thermal components will be mandatory for simulating accurately the global dynamical processes in clusters. In this review, we summarise the results obtained with the simulations of the formation of galaxy clusters which address the issues of shocks, magnetic field, cosmic ray particles and turbulence.Comment: 27 pages, 16 figures, accepted for publication in Space Science Reviews, special issue "Clusters of galaxies: beyond the thermal view", Editor J.S. Kaastra, Chapter 15; work done by an international team at the International Space Science Institute (ISSI), Bern, organised by J.S. Kaastra, A.M. Bykov, S. Schindler & J.A.M. Bleeke

Assessing the feasibility of interrupting the transmission of soil-transmitted helminths through mass drug administration: The DeWorm3 cluster randomized trial protocol

DeWorm3 collectionThe file attached is the Published/publisher’s pdf version of the article.© 2018 Ásbjörnsdóttir et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited